In the present times, the world is facing substantial health, nutritional and agrarian challenges that are further complicated by the looming threat of climate change, which is expected to compound all kinds of problems that face our civilisations and existence. In this context, it is extremely important to review our strategies, development paths and also inform planning accordingly. One of the major human activities that affect all the three challenges mentioned, above, viz. health, nutrition and agrarian economy is agricultural policies and practices. This paper collates literature, secondary evidence, and rationale towards a possible shift in agriculture production, policy and strategies towards climate-smart and high-nutrient content millets, as part of the solution to these complex challenges for India, with emphasis on the North East Region (NER).